Linked Life Data

2115497

Source:http://linkedlifedata.com/resource/pubmed/id/2115497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-28
pubmed:abstractText
Polyclonal antibodies to a purified neurotoxic phospholipase A2 (PLA2), VRV PL-VIIIa, from Vipera russelli venom were raised in rabbits. Anti-PL-VIIIa-Ig (gamma-globulin fraction of rabbit antiserum injected with VRV PL-VIIIa) selectively neutralized the neurotoxicity of VRV PL-VIIIa, VRV PL-V, VRV PL-VI (neurotoxic PLA2 of V. russelli venom) and whole V. russelli venom without affecting their PLA2 activity, which clearly demonstrates that the catalytic site and the neurotoxic site (the site through which the PLA2 binds to the nervous system) are distinct on a PLA2 molecule. Anti-PL-VIIIa Ig did not have any effect on the oedema-inducing activity and indirect haemolytic activity of VRV PL-VIIIa, VRV PL-V and VRV PL-VI, which are attributed to the PLA2 activity of the peptide, but inhibited their anti-coagulant potency.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Antibodies to a phospholipase A2 from Vipera russelli selectively neutralize venom neurotoxicity.
pubmed:affiliation
Department of Studies in Biochemistry, University of Mysore, Manasagangothri, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't