|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021469,
umls-concept:C0021747,
umls-concept:C0033268,
umls-concept:C0205250,
umls-concept:C0439662,
umls-concept:C0597357,
umls-concept:C1171362,
umls-concept:C1415900,
umls-concept:C1416942,
umls-concept:C1515670,
umls-concept:C1551336,
umls-concept:C1956385,
umls-concept:C2587213
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-12-14
|
|
pubmed:abstractText |
Plasmacytoid dendritic cells (pDCs) are a subset of dendritic cells endowed with the capacity of producing large amounts of IFN?. Here we show that the Leukocyte-Associated Ig-like Receptor-1 (LAIR-1) is abundantly expressed on pDCs (the highest expression among all leukocytes) and its cross-linking inhibits IFN? production in response to Toll-like receptor ligands. Remarkably, LAIR-1 expression in pDCs is down-regulated in the presence of interleukin (IL)-3, thus indicating coordinated functions with NKp44, another pDC inhibitory receptor, which is conversely induced by IL-3. Nevertheless, the expression of NKp44 in pDCs isolated from secondary lymphoid organs, which is thought to be influenced by IL-3, is not coupled to a decreased expression of LAIR-1. Interestingly, pDCs isolated from peripheral blood of systemic lupus erithematosus (SLE) patients express lower levels of LAIR-1 while displaying slight but consistent expression of NKp44, usually undetectable on pDCs derived from healthy donors. Using sera derived from SLE patients, we show that LAIR-1 and NKp44 display synergistic inhibitory effects on IFN? production by interleukin IL-3 cultured pDCs stimulated with DNA immunocomplexes. In conclusion, our results indicate that the inhibitory function of LAIR-1 may play a relevant role in the mechanisms controlling IFN? production by pDCs both in normal and pathological innate immune responses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
pubmed-author:BonaccorsiIreneI,
pubmed-author:CantoniClaudiaC,
pubmed-author:CarregaPaoloP,
pubmed-author:CavaliereRiccardoR,
pubmed-author:ConteRomanaR,
pubmed-author:FerlazzoGuidoG,
pubmed-author:GattornoMarcoM,
pubmed-author:LuiGabrielleG,
pubmed-author:MartiniAlbertoA,
pubmed-author:MingariMaria CristinaMC,
pubmed-author:MorettaAlessandroA,
pubmed-author:NavarraMicheleM,
pubmed-author:OliveriDanielaD,
pubmed-author:TraggiaiElisabettaE
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e15080
|
|
pubmed:meshHeading |
pubmed-meshheading:21151495-Cells, Cultured,
pubmed-meshheading:21151495-Dendritic Cells,
pubmed-meshheading:21151495-Flow Cytometry,
pubmed-meshheading:21151495-Fluorescent Antibody Technique,
pubmed-meshheading:21151495-Gene Expression,
pubmed-meshheading:21151495-Humans,
pubmed-meshheading:21151495-Interferon-alpha,
pubmed-meshheading:21151495-Killer Cells, Natural,
pubmed-meshheading:21151495-Lupus Erythematosus, Systemic,
pubmed-meshheading:21151495-Lymphoid Tissue,
pubmed-meshheading:21151495-Natural Cytotoxicity Triggering Receptor 2,
pubmed-meshheading:21151495-Receptors, Immunologic,
pubmed-meshheading:21151495-Reverse Transcriptase Polymerase Chain Reaction
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFN? production.
|
|
pubmed:affiliation |
Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
