|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2011-6-17
|
|
pubmed:abstractText |
Virus-specific T cells capable of controlling HBV and eliminating hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T cell receptor (TCR) gene transfer can reconstitute HBV-specific T cell immunity in lymphocytes of chronic HBV patients and investigate whether HCC cells with natural HBV-DNA integration can be recognized by genetically modified T cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
pubmed-author:BertolettiAntonioA,
pubmed-author:ChiaAdelineA,
pubmed-author:GehringAdam JAJ,
pubmed-author:HoZi ZongZZ,
pubmed-author:KohSareneS,
pubmed-author:LimSeng GeeSG,
pubmed-author:MainiMala KMK,
pubmed-author:RuedlChristianeC,
pubmed-author:StaussHansH,
pubmed-author:TeohDeniseD,
pubmed-author:XueShao-AnSA
|
|
pubmed:copyrightInfo |
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
55
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
103-10
|
|
pubmed:meshHeading |
pubmed-meshheading:21145860-Carcinoma, Hepatocellular,
pubmed-meshheading:21145860-Cell Line,
pubmed-meshheading:21145860-Cell Line, Tumor,
pubmed-meshheading:21145860-Gene Expression,
pubmed-meshheading:21145860-Genetic Engineering,
pubmed-meshheading:21145860-Genetic Vectors,
pubmed-meshheading:21145860-HLA-A2 Antigen,
pubmed-meshheading:21145860-Hepatitis B, Chronic,
pubmed-meshheading:21145860-Hepatitis B Surface Antigens,
pubmed-meshheading:21145860-Hepatitis B virus,
pubmed-meshheading:21145860-Humans,
pubmed-meshheading:21145860-Immunity, Cellular,
pubmed-meshheading:21145860-Liver Neoplasms,
pubmed-meshheading:21145860-Receptors, Antigen, T-Cell,
pubmed-meshheading:21145860-T-Lymphocytes,
pubmed-meshheading:21145860-Transduction, Genetic
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines.
|
|
pubmed:affiliation |
Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
