| pubmed-article:21140599 | pubmed:abstractText | Theiler’s murine encephalomyelitis virus is divided into two subgroups, TO and GDVII, inducing subgroup-specific diseases. In order to investigate the role(s) of nonstructural proteins of TMEV, L and L(?), leaders of two subgroups, were separately expressed with or without L(?) in BHK-21 cells. Expression of L increased the number of apoptotic cells. L(?)/BHK-21 cells constitutively expressing L(?) showed the decrease in cell death induced by L. These results suggest that L and L(?) regulate apoptosis during viral infection and contribute to TMEV subgroup-specific biological activities. | lld:pubmed |
