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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-5-23
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pubmed:abstractText |
Endothelial dysfunction is a well known risk factor for atherosclerosis. Uric acid levels are associated with endothelial dysfunction and atherosclerosis even if in physiological range. Xanthine oxidase inhibition with allopurinol decreases uric acid levels and oxidative stress and improves endothelial function. We have investigated the effect of high-dose and long-term allopurinol therapy on endothelial function in diabetic normotensive patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1651-1999
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pubmed:author |
pubmed-author:AkpekMahmutM,
pubmed-author:ArdicIdrisI,
pubmed-author:DoganAliA,
pubmed-author:DoganSerapS,
pubmed-author:DogduOrhanO,
pubmed-author:KalayNihatN,
pubmed-author:KaradagZakirZ,
pubmed-author:KayaMehmet GungorMG,
pubmed-author:KilincYusufY,
pubmed-author:OguzhanAbdurrahmanA,
pubmed-author:OzdogruIbrahimI,
pubmed-author:YarliogluesMikailM,
pubmed-author:ZencirCemilC
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-7
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pubmed:meshHeading |
pubmed-meshheading:21133824-Allopurinol,
pubmed-meshheading:21133824-Blood Flow Velocity,
pubmed-meshheading:21133824-Blood Pressure,
pubmed-meshheading:21133824-Brachial Artery,
pubmed-meshheading:21133824-Diabetes Mellitus,
pubmed-meshheading:21133824-Drug Administration Schedule,
pubmed-meshheading:21133824-Endothelium, Vascular,
pubmed-meshheading:21133824-Enzyme Inhibitors,
pubmed-meshheading:21133824-Female,
pubmed-meshheading:21133824-Hemoglobin A, Glycosylated,
pubmed-meshheading:21133824-Humans,
pubmed-meshheading:21133824-Male,
pubmed-meshheading:21133824-Middle Aged,
pubmed-meshheading:21133824-Nitrates,
pubmed-meshheading:21133824-Oxidative Stress,
pubmed-meshheading:21133824-Turkey,
pubmed-meshheading:21133824-Uric Acid,
pubmed-meshheading:21133824-Vasodilation,
pubmed-meshheading:21133824-Xanthine Oxidase
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pubmed:year |
2011
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pubmed:articleTitle |
Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients.
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pubmed:affiliation |
Department of Cardiology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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