Source:http://linkedlifedata.com/resource/pubmed/id/21129206
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-12-23
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| pubmed:abstractText |
In candidate-gene association studies of single nucleotide polymorphisms (SNPs), multilocus analyses are frequently of high dimensionality when considering haplotypes or haplotype pairs (diplotypes) and differing modes of expression. Often, while candidate genes are selected based on their biological involvement in a given pathway, little is known about the functionality of SNPs to guide association studies. Investigators face the challenge of exploring multiple SNP models to elucidate which variants, independently or in combination, might be associated with a disease of interest. A data mining module, hapConstructor (freely-available in Genie software) performs systematic construction and association testing of multilocus genotype data in a Monte Carlo framework. Our objective was to assess its utility to guide statistical analyses of haplotypes within a candidate region (or combined genotypes across candidate genes) beyond that offered by a standard logistic regression approach.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1471-2350
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
170
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| pubmed:meshHeading |
pubmed-meshheading:21129206-Adult,
pubmed-meshheading:21129206-Aged,
pubmed-meshheading:21129206-Case-Control Studies,
pubmed-meshheading:21129206-Colonic Neoplasms,
pubmed-meshheading:21129206-Female,
pubmed-meshheading:21129206-Genetic Association Studies,
pubmed-meshheading:21129206-Genetic Loci,
pubmed-meshheading:21129206-Genotype,
pubmed-meshheading:21129206-Haplotypes,
pubmed-meshheading:21129206-Humans,
pubmed-meshheading:21129206-I-kappa B Kinase,
pubmed-meshheading:21129206-Inflammation,
pubmed-meshheading:21129206-Interleukin-6,
pubmed-meshheading:21129206-Interviews as Topic,
pubmed-meshheading:21129206-Logistic Models,
pubmed-meshheading:21129206-Male,
pubmed-meshheading:21129206-Middle Aged,
pubmed-meshheading:21129206-Monte Carlo Method,
pubmed-meshheading:21129206-NF-kappa B p50 Subunit,
pubmed-meshheading:21129206-Polymorphism, Single Nucleotide,
pubmed-meshheading:21129206-Rectal Neoplasms,
pubmed-meshheading:21129206-Risk Factors,
pubmed-meshheading:21129206-Software
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| pubmed:year |
2010
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| pubmed:articleTitle |
Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor.
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| pubmed:affiliation |
Epidemiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. karen.curtin@hsc.utah.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
|