Linked Life Data

2112731

Source:http://linkedlifedata.com/resource/pubmed/id/2112731

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-7-16
pubmed:abstractText
The effect of administration of estradiol (E2) alone or combined with progesterone upon the circadian rhythm of oxytocin concentrations in cerebrospinal fluid (CSF) was examined in adult ovariectomized rhesus monkeys bearing temporary subarachnoid catheters and maintained in a constant photoperiod (lights on 06.00-18.00 h). Animals were subcutaneously implanted with silastic capsules containing 17 beta-E2 for 6 days and progesterone for the last 3 days of E2 administration. Hourly samples of CSF were collected before, during and after gonadal steroid administration and measured for oxytocin by RIA and reverse-phase high-performance liquid chromatography (RP-HPLC). A significant increase in the serum concentration of E2 and the plasma concentration of oxytocin neurophysin, but not the plasma concentration of oxytocin, was found during gonadal steroid administration. Each animal displayed a dirunal pattern of secretion of oxytocin in CSF with peak and trough levels during light and dark hours, respectively. No significant differences were found across experimental conditions in the following CSF oxytocin parameters: mean level of oxytocin in CSF during the light, dark, or light and dark hours combined; the daily phase or amplitude of the CSF oxytocin rhythm; the peak or nadir concentration of oxytocin in CSF; or the total amount of oxytocin secreted into the CSF as expressed as the area under the curve (multivariate repeated measures ANOVA). The CSF oxytocin parameters in the animals that were restudied using empty silastic implants were not significantly different across time (multivariate repeated measures ANOVA).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
543-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of estradiol and progesterone administration upon the circadian rhythm of oxytocin in the cerebrospinal fluid of rhesus monkeys.
pubmed:affiliation
Department of Medicine, University of Pittsburgh School of Medicine, Pa.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.