21124796

Source:http://linkedlifedata.com/resource/pubmed/id/21124796

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001721, umls-concept:C0017262, umls-concept:C0030567, umls-concept:C0056912, umls-concept:C0185117, umls-concept:C0285890, umls-concept:C0598864, umls-concept:C0699748, umls-concept:C2349975, umls-concept:C2911684
pubmed:issue	11
pubmed:dateCreated	2010-12-2
pubmed:abstractText	Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson's disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic PD. CpG methylation in the promoter region may also influence SNCA expression.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101285081
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/alpha-Synuclein
pubmed:status	MEDLINE
pubmed:issn	1932-6203
pubmed:author	pubmed-author:DateHidetoshiH, pubmed-author:IwataAtsushiA, pubmed-author:KurisakiHiroshiH, pubmed-author:MatsumotoLumineL, pubmed-author:TakumaHiroshiH, pubmed-author:TamaokaAkiraA, pubmed-author:TsujiShojiS
pubmed:issnType	Electronic
pubmed:volume	5
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	e15522
pubmed:meshHeading	pubmed-meshheading:21124796-Aged, pubmed-meshheading:21124796-Aged, 80 and over, pubmed-meshheading:21124796-Animals, pubmed-meshheading:21124796-CpG Islands, pubmed-meshheading:21124796-DNA Methylation, pubmed-meshheading:21124796-Dopamine, pubmed-meshheading:21124796-Female, pubmed-meshheading:21124796-Gene Expression Regulation, pubmed-meshheading:21124796-Genetic Predisposition to Disease, pubmed-meshheading:21124796-HEK293 Cells, pubmed-meshheading:21124796-HeLa Cells, pubmed-meshheading:21124796-Humans, pubmed-meshheading:21124796-Male, pubmed-meshheading:21124796-Mice, pubmed-meshheading:21124796-Mice, Inbred C57BL, pubmed-meshheading:21124796-Middle Aged, pubmed-meshheading:21124796-Parkinson Disease, pubmed-meshheading:21124796-Postmortem Changes, pubmed-meshheading:21124796-alpha-Synuclein
pubmed:year	2010
pubmed:articleTitle	CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.
pubmed:affiliation	Division of Neuroscience, Department of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't