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pubmed-article:2112423pubmed:abstractTextTransforming growth factor-beta (TGF-beta) is a multifunctional peptide regulating several processes in ovarian cells. The growth of ovarian carcinoma cell lines (OVCAR-3, HTB-77, 2780 and CRL-1572) was reduced by TGF-beta in a dose related manner. The antiproliferative activity was not improved by combination with other biological response modifiers. Treatment with TGF-beta augmented the expression of interferon-gamma induced class I and II antigens of the major histocompatibility complex. The presentation of another antigen namely the tumor marker CA-125 on the cell surface was markedly reduced by TGF-beta.lld:pubmed
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pubmed-article:2112423pubmed:articleTitleTransforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression.lld:pubmed
pubmed-article:2112423pubmed:affiliationDepartment of Obstetrics and Gynecology, Innsbruck University Clinic, Austria.lld:pubmed
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