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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1990-7-13
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pubmed:abstractText |
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide regulating several processes in ovarian cells. The growth of ovarian carcinoma cell lines (OVCAR-3, HTB-77, 2780 and CRL-1572) was reduced by TGF-beta in a dose related manner. The antiproliferative activity was not improved by combination with other biological response modifiers. Treatment with TGF-beta augmented the expression of interferon-gamma induced class I and II antigens of the major histocompatibility complex. The presentation of another antigen namely the tumor marker CA-125 on the cell surface was markedly reduced by TGF-beta.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
51
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2112423-Antigens, Neoplasm,
pubmed-meshheading:2112423-Antigens, Surface,
pubmed-meshheading:2112423-Cell Division,
pubmed-meshheading:2112423-Cell Survival,
pubmed-meshheading:2112423-Female,
pubmed-meshheading:2112423-Humans,
pubmed-meshheading:2112423-Interferon-gamma,
pubmed-meshheading:2112423-Major Histocompatibility Complex,
pubmed-meshheading:2112423-Ovarian Neoplasms,
pubmed-meshheading:2112423-Recombinant Proteins,
pubmed-meshheading:2112423-Transforming Growth Factors,
pubmed-meshheading:2112423-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Transforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Innsbruck University Clinic, Austria.
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pubmed:publicationType |
Journal Article
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