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pubmed-article:21121304pubmed:abstractTextMolecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2-4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (approximately 130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.lld:pubmed
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pubmed-article:21121304pubmed:pagination8118-23lld:pubmed
pubmed-article:21121304pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:21121304pubmed:articleTitleA facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging.lld:pubmed
pubmed-article:21121304pubmed:affiliationC-TRAIN and Division of Cardiology, Washington University School of Medicine, St. Louis, MO 63108, USA.lld:pubmed
pubmed-article:21121304pubmed:publicationTypeJournal Articlelld:pubmed
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