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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-2
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pubmed:abstractText |
Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2-4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (approximately 130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA119342,
http://linkedlifedata.com/resource/pubmed/grant/EB008085,
http://linkedlifedata.com/resource/pubmed/grant/HL073646,
http://linkedlifedata.com/resource/pubmed/grant/NS059302,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB000712-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB008085-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL094470-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL094470-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS059302-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS059302-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS059302-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS059302-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS059302-05,
http://linkedlifedata.com/resource/pubmed/grant/R01EB000712,
http://linkedlifedata.com/resource/pubmed/grant/R01NS046214,
http://linkedlifedata.com/resource/pubmed/grant/U54 CA136398
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-12541130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-12808463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-16823374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-17292107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-17439359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-17716144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-17943716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-18084605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-18163798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-18468106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-18772918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-18981701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19021413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19072058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19268515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19566311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19801751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19809459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-19809462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21121304-8551984
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1533-4880
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8118-23
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21121304-Contrast Media,
pubmed-meshheading:21121304-Gold,
pubmed-meshheading:21121304-Lipids,
pubmed-meshheading:21121304-Metal Nanoparticles,
pubmed-meshheading:21121304-Microscopy, Atomic Force,
pubmed-meshheading:21121304-Microscopy, Electron, Transmission,
pubmed-meshheading:21121304-Models, Molecular,
pubmed-meshheading:21121304-Nanoconjugates,
pubmed-meshheading:21121304-Nanotubes,
pubmed-meshheading:21121304-Spectroscopy, Near-Infrared,
pubmed-meshheading:21121304-Tomography
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pubmed:year |
2010
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pubmed:articleTitle |
A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging.
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pubmed:affiliation |
C-TRAIN and Division of Cardiology, Washington University School of Medicine, St. Louis, MO 63108, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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