Linked Life Data

21120262

Source:http://linkedlifedata.com/resource/pubmed/id/21120262

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Novel cryopneumatic technology (CPx) and photopneumatic technology (PPx) have been developed to enhance the permeation of the stratum corneum (SC) and percutaneous drug delivery (PDD). CPx produces micro-cracks at the skin surface by successively freezing and stretching the skin with vacuum suction. PPx combines stretching of the skin by vacuum suction with intense pulsed light. The enhancing effects of CPx and PPx were studied on ex vivo porcine skin and in vivo human skin models. Fluorescent hydrophilic macromolecules (FITC and FITC-Dextran) were used as drug surrogates. Fluorescent images of in vivo experiments show that the enhancing effect of CPx is due to drug permeation through the micro-cracks produced by freezing stretching cycles, while PPx could promote drug permeation through sweat glands. Both ex vivo and in vivo results strongly suggest that CPx and PPx can effectively enhance the permeation of the SC and PDD for the delivery of hydrophilic macromolecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1545-9616
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1528-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Stratum corneum permeation and percutaneous drug delivery of hydrophilic molecules enhanced by cryopneumatic and photopneumatic technologies.
pubmed:affiliation
Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't