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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 1
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pubmed:dateCreated |
2010-11-30
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pubmed:abstractText |
This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Sprague-Dawley male rats (n=30) between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the prechiasmatic cistern. SB-3CT, a selective MMP-9 inhibitor, was injected intraperitoneally after SAH induction. MMP-9 protein expression was measured by western blot; laminin expression and neuronal cells in the cerebral cortex were studied by immunohistochemistry and TUNEL staining at 24h after SAH. MMP-9 expression was increased after SAH and decreased by SB-3CT inhibition at 24h after SAH (P<0.01). Laminin, the substrate of MMP-9, was decreased at 24h after SAH, and SB-3CT prevented laminin degradation. The number of TUNEL-positive neurons in cerebral cortex was increased after SAH and decreased by SB-3CT (P<0.01). MMP-9 may be involved in EBI after SAH and inhibition of MMP-9 may reduce EBI in cerebral cortex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0065-1419
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-4
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pubmed:meshHeading |
pubmed-meshheading:21116920-Analysis of Variance,
pubmed-meshheading:21116920-Animals,
pubmed-meshheading:21116920-Brain Injuries,
pubmed-meshheading:21116920-Cerebral Cortex,
pubmed-meshheading:21116920-Disease Models, Animal,
pubmed-meshheading:21116920-Down-Regulation,
pubmed-meshheading:21116920-Enzyme Inhibitors,
pubmed-meshheading:21116920-Heterocyclic Compounds, 1-Ring,
pubmed-meshheading:21116920-In Situ Nick-End Labeling,
pubmed-meshheading:21116920-Laminin,
pubmed-meshheading:21116920-Male,
pubmed-meshheading:21116920-Matrix Metalloproteinase 9,
pubmed-meshheading:21116920-Neurons,
pubmed-meshheading:21116920-Rats,
pubmed-meshheading:21116920-Rats, Sprague-Dawley,
pubmed-meshheading:21116920-Subarachnoid Hemorrhage,
pubmed-meshheading:21116920-Sulfones
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pubmed:year |
2011
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pubmed:articleTitle |
Matrix metalloproteinase 9 inhibition reduces early brain injury in cortex after subarachnoid hemorrhage.
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pubmed:affiliation |
Department of Neurosurgery, First Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
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pubmed:publicationType |
Journal Article
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