Source:http://linkedlifedata.com/resource/pubmed/id/21116678
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2011-2-22
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pubmed:abstractText |
Apoptosis is a vital component in the evolutionarily conserved host defense system. Apoptosis is the guardian of tissue integrity by removing unfit and injured cells without evoking inflammation. However, apoptosis seems to be a double-edged sword since during low-level chronic stress, such as in aging, increased resistance to apoptosis can lead to the survival of functionally deficient, post-mitotic cells with damaged housekeeping functions. Senescent cells are remarkably resistant to apoptosis, and several studies indicate that host defense mechanisms can enhance anti-apoptotic signaling, which subsequently induces a senescent, pro-inflammatory phenotype during the aging process. At the molecular level, age-related resistance to apoptosis involves (1) functional deficiency in p53 network, (2) increased activity in the NF-?B-IAP/JNK axis, and (3) changes in molecular chaperones, microRNAs, and epigenetic regulation. We will discuss the molecular basis of age-related resistance to apoptosis and emphasize that increased resistance could enhance the aging process.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1420-9071
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1021-31
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pubmed:meshHeading |
pubmed-meshheading:21116678-Aging,
pubmed-meshheading:21116678-Animals,
pubmed-meshheading:21116678-Apoptosis,
pubmed-meshheading:21116678-Cell Aging,
pubmed-meshheading:21116678-Epigenesis, Genetic,
pubmed-meshheading:21116678-Humans,
pubmed-meshheading:21116678-MAP Kinase Kinase 4,
pubmed-meshheading:21116678-Molecular Chaperones,
pubmed-meshheading:21116678-Morphogenesis,
pubmed-meshheading:21116678-NF-kappa B,
pubmed-meshheading:21116678-Neoplasms,
pubmed-meshheading:21116678-Tumor Suppressor Protein p53
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pubmed:year |
2011
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pubmed:articleTitle |
Apoptosis and aging: increased resistance to apoptosis enhances the aging process.
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pubmed:affiliation |
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. antero.salminen@uef.fi
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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