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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-11-25
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pubmed:abstractText |
The ?L?2-integrin LFA-1 (CD11a/CD18) is known as an important molecule for leukocyte migration. However, the precise role of LFA-1 in the pathogenesis of EAE has so far remained unclear. We describe here the disease development in LFA-1(-/-) mice compared with WT controls. Ablation of LFA-1 resulted in more severe EAE with increased demyelination and increased numbers of myelin oligodendrocyte glycoprotein-reactive CD4(+) T cells in the CNS. However, the production of the pro-inflammatory cytokines IL-17 and IFN-? was unchanged on the level of antigen-specific T cells. Interestingly, LFA-1-deficient mice showed a clearly reduced frequency of Treg in the inflamed CNS. Moreover, Treg counts in spleens and thymi of unimmunized LFA-1(-/-) mice were lower in comparison to the WT controls, indicating an impairment of Treg generation. In combination, these results suggest a substantial role of LFA-1 in Treg generation and subsequent expansion of effector T cells and highlight the importance of Treg in limiting EAE.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1521-4141
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3403-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21108463-Animals,
pubmed-meshheading:21108463-Brain,
pubmed-meshheading:21108463-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21108463-Cell Count,
pubmed-meshheading:21108463-Cell Differentiation,
pubmed-meshheading:21108463-Cells, Cultured,
pubmed-meshheading:21108463-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:21108463-Inflammation Mediators,
pubmed-meshheading:21108463-Interferon-gamma,
pubmed-meshheading:21108463-Interleukin-17,
pubmed-meshheading:21108463-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:21108463-Mice,
pubmed-meshheading:21108463-Mice, Inbred C57BL,
pubmed-meshheading:21108463-Mice, Knockout,
pubmed-meshheading:21108463-Myelin Proteins,
pubmed-meshheading:21108463-Myelin-Associated Glycoprotein,
pubmed-meshheading:21108463-Spinal Cord,
pubmed-meshheading:21108463-T-Lymphocytes, Regulatory
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pubmed:year |
2010
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pubmed:articleTitle |
Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE.
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pubmed:affiliation |
Robert Koch Institute, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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