Linked Life Data

21105029

Source:http://linkedlifedata.com/resource/pubmed/id/21105029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-27
pubmed:abstractText
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2) , pancreatic cancer risk was 47% higher (95%CI:23-75%) among obese (BMI ? 30 kg/m(2) ) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI ? 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2) ). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2) ) and not obese at baseline (BMI < 30 kg/m(2) ), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ? 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1097-0215
pubmed:author
pubmed-author:AndersonKristin EKE, pubmed-author:BernsteinLeslieL, pubmed-author:CalleEugenia EEE, pubmed-author:EnglishDallas RDR, pubmed-author:FolsomAaron RAR, pubmed-author:FreudenheimJo LJL, pubmed-author:FuchsCharles SCS, pubmed-author:GenkingerJeanine MJM, pubmed-author:GilesGraham GGG, pubmed-author:GiovannucciEdwardE, pubmed-author:Horn-RossPamela LPL, pubmed-author:LarssonSusanna CSC, pubmed-author:LeitzmannMichaelM, pubmed-author:MännistöSatuS, pubmed-author:MarshallJames RJR, pubmed-author:MillerAnthony BAB, pubmed-author:PatelAlpa VAV, pubmed-author:RohanThomas ETE, pubmed-author:Smith-WarnerStephanie ASA, pubmed-author:SpiegelmanDonnaD, pubmed-author:Stolzenberg-SolomonRachael ZRZ, pubmed-author:VerhageBas A JBA, pubmed-author:VirtamoJarmoJ, pubmed-author:WillcoxBradley JBJ, pubmed-author:WolkAlicjaA, pubmed-author:ZieglerRegina GRG, pubmed-author:van den BrandtPiet APA
pubmed:copyrightInfo
Copyright © 2010 UICC.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1708-17
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk.
pubmed:affiliation
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. jg3081@columbia.edu
pubmed:publicationType
Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural