Source:http://linkedlifedata.com/resource/pubmed/id/21104440
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2011-5-2
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| pubmed:abstractText |
The purpose of this study was to assess the value of cytokeratin 19 (CK19) and matrix metalloproteinase 2 (MMP-2) in predicting lymph node metastasis (LNM) and survival after curative resection in hepatocellular carcinoma (HCC) patients. Expression of CK19 and MMP-2 in tumor tissue was assessed through immunohistochemical staining of tissue microarrays (TMAs), which were constructed using samples from HCC patients with (n = 123) and without (n = 145) LNM. Positive CK19 expression was correlated with LNM (P < 0.001), satellite lesions (P = 0.016), and lymph node location (P = 0.039). High MMP-2 expression correlated with LNM (P < 0.001), UICC T stage (P = 0.023), and Edmondson grade (P = 0.022). Moreover, CK19 expression correlated with MMP-2 expression (P = 0.033). CK19 and MMP-2 expression were predictive of HCC LNM (AUC: 0.640; 95% CI: 0.572-0.707; P < 0.001 and AUC: 0.611; 95% CI: 0.544-0.679; P = 0.002, respectively). CK19 and MMP-2 expression were independent prognostic factors for disease-free survival (P = 0.031 and P = 0.012, respectively) and overall survival (P = 0.013 and P = 0.018, respectively) in HCC patients with LNM. CK19 expression (P < 0.001), MMP-2 expression (P = 0.006), and UICC T stage (P < 0.001) were independent risk factors for developing LNM in HCC. These findings show that CK19 and MMP-2 expression may be beneficial in predicting HCC LNM and survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1573-4978
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
38
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3531-9
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| pubmed:meshHeading |
pubmed-meshheading:21104440-Adolescent,
pubmed-meshheading:21104440-Adult,
pubmed-meshheading:21104440-Aged,
pubmed-meshheading:21104440-Aged, 80 and over,
pubmed-meshheading:21104440-Carcinoma, Hepatocellular,
pubmed-meshheading:21104440-Child,
pubmed-meshheading:21104440-Disease-Free Survival,
pubmed-meshheading:21104440-Female,
pubmed-meshheading:21104440-Humans,
pubmed-meshheading:21104440-Keratin-19,
pubmed-meshheading:21104440-Liver Neoplasms,
pubmed-meshheading:21104440-Lymph Nodes,
pubmed-meshheading:21104440-Lymphatic Metastasis,
pubmed-meshheading:21104440-Male,
pubmed-meshheading:21104440-Matrix Metalloproteinase 2,
pubmed-meshheading:21104440-Middle Aged,
pubmed-meshheading:21104440-Retrospective Studies,
pubmed-meshheading:21104440-Young Adult
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Expression of cytokeratin 19 and matrix metalloproteinase 2 predicts lymph node metastasis in hepatocellular carcinoma.
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| pubmed:affiliation |
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, China.
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| pubmed:publicationType |
Journal Article
|