|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
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|
pubmed:dateCreated |
1990-5-29
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|
pubmed:abstractText |
The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0031-6970
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
93-5
|
|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2109700-Aged,
pubmed-meshheading:2109700-Binding, Competitive,
pubmed-meshheading:2109700-Blood Proteins,
pubmed-meshheading:2109700-Dialysis,
pubmed-meshheading:2109700-Diuretics,
pubmed-meshheading:2109700-Glyburide,
pubmed-meshheading:2109700-Heart Failure,
pubmed-meshheading:2109700-Humans,
pubmed-meshheading:2109700-Hydrogen-Ion Concentration,
pubmed-meshheading:2109700-Male,
pubmed-meshheading:2109700-Metolazone,
pubmed-meshheading:2109700-Protein Binding
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Possible protein binding displacement interaction between glibenclamide and metolazone.
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|
pubmed:affiliation |
Department of Clinical Pharmacology, Glenfield General Hospital, Leicester, UK.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|
