Linked Life Data

21093329

Source:http://linkedlifedata.com/resource/pubmed/id/21093329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-16
pubmed:abstractText
It has been reported that the whisker pad (WP) area, which is innervated by the second branch of the trigeminal nerve, shows allodynia/hyperalgesia following transection of the mental nerve (MN: the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain induction still remain unclear. Glia and cytokines are known to facilitate perception of noxious input, raising a possibility that these non-neuronal elements are involved in the induction and spread of allodynia/hyperalgesia at non-injured skin territory. One day after MN transection, tactile allodynia/hyperalgesia developed on the ipsilateral WP area, which is in the non-injured skin territory. The tactile allodynia/hyperalgesia lasted for more than 56 days. In response to MN transection, astrocytes and microglia appeared to be in an activated state, and interleukin (IL)-1beta was up-regulated in astrocytes in the trigeminal subnucleus caudalis (Vc). Allodynia/hyperalgesia at WP area induced by MN transection was attenuated dose-dependently by IL-1 receptor antagonist IL-1ra (i.t., 0.05, 0.5, and 5 pg/rat). Fos-like immunoreactive (Fos-Li) neurons were observed in the Vc after non-noxious mechanical stimulation of the WP area in the rats with MN transection. Administration of IL-1ra also attenuated the number of Fos-Li neurons dose-dependently. Administration of a noncompetitive antagonist of NMDA receptors MK-801 (i.t., 5 ?g/rat) reversed allodynia/hyperalgesia. IL-1 receptor type I (IL-1RI) was localized in Fos- and phospho NR1-immunoreactive neurons. These results suggest that IL-1beta in the Vc plays an important role in the development of extra-territorial tactile allodynia/hyperalgesia after MN transection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1532-2149
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
467.e1-14
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21093329-Animals, pubmed-meshheading:21093329-Antirheumatic Agents, pubmed-meshheading:21093329-Astrocytes, pubmed-meshheading:21093329-Disease Models, Animal, pubmed-meshheading:21093329-Dizocilpine Maleate, pubmed-meshheading:21093329-Excitatory Amino Acid Antagonists, pubmed-meshheading:21093329-Hyperalgesia, pubmed-meshheading:21093329-Injections, Spinal, pubmed-meshheading:21093329-Interleukin 1 Receptor Antagonist Protein, pubmed-meshheading:21093329-Interleukin-1beta, pubmed-meshheading:21093329-Mandible, pubmed-meshheading:21093329-Microglia, pubmed-meshheading:21093329-Rats, pubmed-meshheading:21093329-Trigeminal Caudal Nucleus, pubmed-meshheading:21093329-Trigeminal Nerve Injuries, pubmed-meshheading:21093329-Up-Regulation, pubmed-meshheading:21093329-Vibrissae
pubmed:year
2011
pubmed:articleTitle
IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury.
pubmed:affiliation
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Science, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan.
pubmed:publicationType
Journal Article