Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-17
pubmed:abstractText
Depression is an under-recognized comorbidity associated with amyotrophic lateral sclerosis (ALS). The goals of this study were to prospectively estimate the prevalence of depression and other ALS related symptoms and to study the impact of depression on enrollment in research studies. One hundred and twenty-seven people with ALS completed the ALS Depression Inventory (ADI-12) and answered questions about ALS related symptoms and research study enrollment preferences. Demographics, ALS symptoms, medications, functional status, and research enrollment were compared between depressed and non-depressed patients. Results showed that the prevalence of mild and severe depression was 29% and 6%, respectively. More than one-third of our ALS patients were receiving anti-depressants to treat depression, sialorrhea, and pseudobulbar affect. Depression prevalence was not correlated with disease duration or progression. Except for anxiety, none of the ALS related symptoms predicted depression. The presence of depression did not have an effect on the decision to enroll in research studies. In conclusion, major depression is less common in our ALS cohort than in the general population. The diagnosis of depression can be masked by some ALS related symptoms and it has no impact on enrollment in ALS clinical trials.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-10227631, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-10817793, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-12525733, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-15489393, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-15914823, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-16009886, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-16093409, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-1637252, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-17381183, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-17718691, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-18262283, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-18608092, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-7807156, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-8274106, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-8721801, http://linkedlifedata.com/resource/pubmed/commentcorrection/21091399-9001479
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1471-180X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-12
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Depression in amyotrophic lateral sclerosis.
pubmed:affiliation
Massachusetts General Hospital, Harvard Medical School, Boston, USA. NATASSI@PARTNERS.ORG
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural