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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-3
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pubmed:abstractText |
Oxidative stress plays an important role in the pathogenesis of various ocular diseases such as retinopathy, glaucoma, and age-related macular degeneration. Activating transcription factor 4 (ATF4) is induced by various stressors, including endoplasmic reticulum (ER) and oxidative stress, and ATF4 expression is regulated translationally through the PERK pathway of eIF2? phosphorylation. Transcriptional regulation of the ATF4 gene under oxidative stress was investigated in human papillomavirus 16 (HPV-16)-transformed retinal pigment epithelial ARPE-19/HPV-16 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1226-34
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pubmed:meshHeading |
pubmed-meshheading:21087962-Activating Transcription Factor 4,
pubmed-meshheading:21087962-Anoxia,
pubmed-meshheading:21087962-Blotting, Western,
pubmed-meshheading:21087962-Cell Line, Transformed,
pubmed-meshheading:21087962-Cell Transformation, Viral,
pubmed-meshheading:21087962-Chromatin Immunoprecipitation,
pubmed-meshheading:21087962-Endothelium, Corneal,
pubmed-meshheading:21087962-Enzyme Inhibitors,
pubmed-meshheading:21087962-Gene Expression Regulation,
pubmed-meshheading:21087962-Human papillomavirus 16,
pubmed-meshheading:21087962-Humans,
pubmed-meshheading:21087962-Hydrogen Peroxide,
pubmed-meshheading:21087962-NF-E2-Related Factor 2,
pubmed-meshheading:21087962-Oxidative Stress,
pubmed-meshheading:21087962-Plasmids,
pubmed-meshheading:21087962-Retinal Pigment Epithelium,
pubmed-meshheading:21087962-Thapsigargin,
pubmed-meshheading:21087962-Trabecular Meshwork
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pubmed:year |
2011
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pubmed:articleTitle |
Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells.
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pubmed:affiliation |
Department of Molecular Biology, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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