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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1990-5-2
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pubmed:abstractText |
The multifunctional actions of transforming growth factor beta 1 (TGF-beta 1) indicate that it has a pivotal control function in many physiological and pathological processes. An important property of TGF-beta 1 is its ability to activate its own mRNA expression and thereby increase its own secretion. Two distinct regions of the promoter of the TGF-beta 1 gene are responsive to autoregulation: one 5' to the upstream transcriptional start site and another located between the two major start sites. In both promoter regions, autoinduction is mediated by binding of the AP-1 (Jun-Fos) complex. An important contribution to this positive regulation is the autoactivation of c-jun transcription by AP-1. Cotransfection of antisense c-jun or antisense c-fos expression vectors prevents TGF-beta 1 autoinduction. These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction. Induction of jun expression by TGF-beta 1, as well as jun autoinduction, may amplify the action of TGF-beta 1 during normal development and oncogenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2442615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2498806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2537468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2708352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2725496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2808430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2825349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2839774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2909528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-2964084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3034433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3130660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3135940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3142689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3153459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3194415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3259578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3347253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3497351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3523478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3554236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-3856735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-6313230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2108318-7418005
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1492-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2108318-Adenocarcinoma,
pubmed-meshheading:2108318-Cell Line,
pubmed-meshheading:2108318-DNA-Binding Proteins,
pubmed-meshheading:2108318-Enzyme Induction,
pubmed-meshheading:2108318-Gene Expression,
pubmed-meshheading:2108318-Homeostasis,
pubmed-meshheading:2108318-Humans,
pubmed-meshheading:2108318-Lung Neoplasms,
pubmed-meshheading:2108318-Plasmids,
pubmed-meshheading:2108318-Promoter Regions, Genetic,
pubmed-meshheading:2108318-Protein-Tyrosine Kinases,
pubmed-meshheading:2108318-Proto-Oncogene Proteins,
pubmed-meshheading:2108318-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:2108318-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:2108318-Proto-Oncogenes,
pubmed-meshheading:2108318-RNA, Messenger,
pubmed-meshheading:2108318-Restriction Mapping,
pubmed-meshheading:2108318-Transcription, Genetic,
pubmed-meshheading:2108318-Transcription Factors,
pubmed-meshheading:2108318-Transforming Growth Factors,
pubmed-meshheading:2108318-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
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pubmed:affiliation |
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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