21081230

Source:http://linkedlifedata.com/resource/pubmed/id/21081230

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002045, umls-concept:C0178742, umls-concept:C0184511, umls-concept:C0449432, umls-concept:C0546881, umls-concept:C0872318, umls-concept:C1179435, umls-concept:C1524073, umls-concept:C1548799, umls-concept:C1705248
pubmed:issue	52
pubmed:dateCreated	2010-12-6
pubmed:abstractText	A method for tracking of sample components during liquid chromatography-mass spectrometry (LC-MS) method development has been proposed. The method manages to, fully automatically and without user intervention, find the chromatographic peaks in the data sets, discriminate them to sample components and track them when the separation conditions have been changed. The algorithm utilises the resolution obtained from all considered data sets and has the ability to discriminate the non informative parts. The technique has a great sensitivity even in cases where a majority of the tracked components cannot easily be spotted by means of traditional total ion chromatogram (TIC) or base peak chromatogram (BPC) representations. The method was tested on an experimental sample using six different columns and an average of 79% of the suggested sample components could be successfully tracked at a minimum area of 0.05% of the main component in the sample. 66 components with 79-92% of the total suggested component area were able to be tracked between all data sets. The method could be used to rapidly investigate selectivity during different types of separation conditions.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9318488
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1873-3778
pubmed:author	pubmed-author:AxelssonBengt-OlofBO, pubmed-author:BylundDanD, pubmed-author:FredrikssonMattias JMJ, pubmed-author:PeterssonPatrikP
pubmed:copyrightInfo	Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType	Electronic
pubmed:day	24
pubmed:volume	1217
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	8195-204
pubmed:meshHeading	pubmed-meshheading:21081230-Algorithms, pubmed-meshheading:21081230-Chromatography, High Pressure Liquid, pubmed-meshheading:21081230-Mass Spectrometry
pubmed:year	2010
pubmed:articleTitle	A component tracking algorithm for accelerated and improved liquid chromatography-mass spectrometry method development.
pubmed:affiliation	Mid Sweden University, Department of Natural Sciences, Engineering and Mathematics, SE-851 70 Sundsvall, Sweden.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't