| pubmed-article:21072821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0346421 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C1513388 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C1521725 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:21072821 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:21072821 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21072821 | pubmed:dateCreated | 2011-1-12 | lld:pubmed |
| pubmed-article:21072821 | pubmed:abstractText | We report a rare pediatric chronic eosinophilic leukemia (CEL) case of an 8-year-old male whose leukemic cells carried t(1; 5)(q21; q33) chromosomal abnormality. Sequencing analysis confirmed a TPM3-PDGFRB fusion, and the breakpoint was the same as adult patient. Targeted therapy with imatinib induced a rapid hematologic response and reduction of TPM3-PDGFRB transcripts as monitored by reverse transcription real-time PCR (RT-qPCR). We then established an RT-qPCR assay applicable to detection of all possible PDGFRB fusions and also validated this assay in the patient. These data should provide a valuable reference for management of pediatric CEL. | lld:pubmed |
| pubmed-article:21072821 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21072821 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072821 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21072821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21072821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21072821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21072821 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21072821 | pubmed:issn | 1545-5017 | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:LiQinggeQ | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:YangRongR | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:TseWilliamW | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:LiZhipengZ | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:LuQuanyiQ | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:YuanRuirongR | lld:pubmed |
| pubmed-article:21072821 | pubmed:author | pubmed-author:ZhaoJiangning... | lld:pubmed |
| pubmed-article:21072821 | pubmed:copyrightInfo | © 2010 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:21072821 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21072821 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:21072821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21072821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21072821 | pubmed:pagination | 463-6 | lld:pubmed |
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| pubmed-article:21072821 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21072821 | pubmed:articleTitle | Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion. | lld:pubmed |
| pubmed-article:21072821 | pubmed:affiliation | Molecular Diagnostics Laboratory, Department of Biomedical Sciences and Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. | lld:pubmed |
| pubmed-article:21072821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21072821 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21072821 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:21072821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7170 | entrezgene:pubmed | pubmed-article:21072821 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21072821 | lld:entrezgene |
