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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-12
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pubmed:abstractText |
We report a rare pediatric chronic eosinophilic leukemia (CEL) case of an 8-year-old male whose leukemic cells carried t(1; 5)(q21; q33) chromosomal abnormality. Sequencing analysis confirmed a TPM3-PDGFRB fusion, and the breakpoint was the same as adult patient. Targeted therapy with imatinib induced a rapid hematologic response and reduction of TPM3-PDGFRB transcripts as monitored by reverse transcription real-time PCR (RT-qPCR). We then established an RT-qPCR assay applicable to detection of all possible PDGFRB fusions and also validated this assay in the patient. These data should provide a valuable reference for management of pediatric CEL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/TPM3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tropomyosin,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1545-5017
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
463-6
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pubmed:meshHeading |
pubmed-meshheading:21072821-Adult,
pubmed-meshheading:21072821-Antineoplastic Agents,
pubmed-meshheading:21072821-Child,
pubmed-meshheading:21072821-Chromosomes, Human, Pair 1,
pubmed-meshheading:21072821-Chromosomes, Human, Pair 5,
pubmed-meshheading:21072821-Chronic Disease,
pubmed-meshheading:21072821-Humans,
pubmed-meshheading:21072821-Hypereosinophilic Syndrome,
pubmed-meshheading:21072821-In Situ Hybridization, Fluorescence,
pubmed-meshheading:21072821-Male,
pubmed-meshheading:21072821-Oncogene Proteins, Fusion,
pubmed-meshheading:21072821-Piperazines,
pubmed-meshheading:21072821-Pyrimidines,
pubmed-meshheading:21072821-RNA, Messenger,
pubmed-meshheading:21072821-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:21072821-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21072821-Translocation, Genetic,
pubmed-meshheading:21072821-Treatment Outcome,
pubmed-meshheading:21072821-Tropomyosin
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pubmed:year |
2011
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pubmed:articleTitle |
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
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pubmed:affiliation |
Molecular Diagnostics Laboratory, Department of Biomedical Sciences and Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports,
Research Support, Non-U.S. Gov't
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