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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-1
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pubmed:abstractText |
The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine ?-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
pubmed-author:AlvarezVictoriaV,
pubmed-author:Arias-VásquezAlejandroA,
pubmed-author:AulchenkoYurii SYS,
pubmed-author:BarberRachelR,
pubmed-author:BelbinOliviaO,
pubmed-author:BretelerMonique MMM,
pubmed-author:BrownKristelleK,
pubmed-author:Cortina-BorjaMarioM,
pubmed-author:CotoEliecerE,
pubmed-author:DeloukasPanosP,
pubmed-author:FRISCHKORNC SCS,
pubmed-author:GwilliamRhianR,
pubmed-author:HammondNaomiN,
pubmed-author:HeunReinhardR,
pubmed-author:IkramM ArfanMA,
pubmed-author:KölschHeikeH,
pubmed-author:KehoePatrick GPG,
pubmed-author:LehmannDonald JDJ,
pubmed-author:LehmannMichael GMG,
pubmed-author:MateoIgnacioI,
pubmed-author:MorganKevinK,
pubmed-author:OulhajAbderrahimA,
pubmed-author:SchuurMaaikeM,
pubmed-author:SmithA DavidAD,
pubmed-author:WardenDonald RDR,
pubmed-author:WilcockGordon KGK,
pubmed-author:van DuijnCornelia MCM
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
162
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pubmed:meshHeading |
pubmed-meshheading:21070631-Aged,
pubmed-meshheading:21070631-Alzheimer Disease,
pubmed-meshheading:21070631-Dopamine beta-Hydroxylase,
pubmed-meshheading:21070631-Epistasis, Genetic,
pubmed-meshheading:21070631-Europe,
pubmed-meshheading:21070631-Female,
pubmed-meshheading:21070631-Genotype,
pubmed-meshheading:21070631-Humans,
pubmed-meshheading:21070631-Interleukin-1alpha,
pubmed-meshheading:21070631-Interleukin-6,
pubmed-meshheading:21070631-Locus Coeruleus,
pubmed-meshheading:21070631-Male,
pubmed-meshheading:21070631-Neurons,
pubmed-meshheading:21070631-Odds Ratio,
pubmed-meshheading:21070631-Polymorphism, Single Nucleotide,
pubmed-meshheading:21070631-Risk Factors,
pubmed-meshheading:21070631-Spain
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pubmed:year |
2010
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pubmed:articleTitle |
The dopamine ?-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project.
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pubmed:affiliation |
Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital (University of Cantabria), 39008 Santander, Spain. combarro@unican.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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