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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-11-29
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pubmed:abstractText |
EphB receptors and their ephrin-B ligands play an important role in nervous system development, as well as synapse formation and plasticity in the adult brain. Recent studies show that intrathecal treatment with EphB-receptor activator ephrinB2-Fc induced thermal hyperalgesia and mechanical allodynia in rat, indicating that ephrin-B2 in small dorsal root ganglia (DRG) neurons and EphB receptors in the spinal cord modulate pain processing. To examine the role of ephrin-B2 in peripheral pain pathways, we deleted ephrin-B2 in Nav1.8+ nociceptive sensory neurons with the Cre-loxP system. Sensory neuron numbers and terminals were examined using neuronal makers. Pain behavior in acute, inflammatory and neuropathic pain models was assessed in the ephrin-B2 conditional knockout (CKO) mice. We also investigated the c-Fos expression and NMDA receptor NR2B phosphorylation in ephrin-B2 CKO mice and littermate controls.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Ephrin-B2,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/NR2B NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/sensory neuron specific (SNS)...
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77
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pubmed:meshHeading |
pubmed-meshheading:21059214-Activating Transcription Factor 3,
pubmed-meshheading:21059214-Acute Disease,
pubmed-meshheading:21059214-Animals,
pubmed-meshheading:21059214-Behavior, Animal,
pubmed-meshheading:21059214-Cell Survival,
pubmed-meshheading:21059214-Disease Models, Animal,
pubmed-meshheading:21059214-Ephrin-B2,
pubmed-meshheading:21059214-Exons,
pubmed-meshheading:21059214-Ganglia, Spinal,
pubmed-meshheading:21059214-Gene Deletion,
pubmed-meshheading:21059214-Glial Fibrillary Acidic Protein,
pubmed-meshheading:21059214-Inflammation,
pubmed-meshheading:21059214-Integrases,
pubmed-meshheading:21059214-Mice,
pubmed-meshheading:21059214-Microglia,
pubmed-meshheading:21059214-Neuralgia,
pubmed-meshheading:21059214-Neurons, Afferent,
pubmed-meshheading:21059214-Nociceptors,
pubmed-meshheading:21059214-Phosphorylation,
pubmed-meshheading:21059214-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:21059214-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:21059214-Sodium Channels,
pubmed-meshheading:21059214-Spinal Cord
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pubmed:year |
2010
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pubmed:articleTitle |
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain.
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pubmed:affiliation |
Molecular Nociception Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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