Linked Life Data

21058511

Source:http://linkedlifedata.com/resource/pubmed/id/21058511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-11-9
pubmed:abstractText
Establishing chromosomal homology in comparative cytogenetics remained speculative until the advent of molecular cytogenetics. Chromosome sorting by flow cytometry and degenerate oligonucleotide primed-PCR (DOP-PCR) brought a significant simplification and impetus to chromosome painting. Comparative chromosome painting has permitted reasonable hypotheses for ancestral karyotypes at many points on the phylogenetic tree of mammals. Derived associations often provided landmarks that showed the route evolution took. More recently hybridization with cloned DNA has provided information on intrachromosomal rearrangements. BAC-FISH allows marker order, in addition to syntenies and associations, to be added to the ancestral karyotypes. Comparisons of marker order across species revealed that centromere shifts (evolutionary new centromeres) are frequent and important phenomena of chromosome evolution. Further comparison between evolutionary new centromeres and clinical neocentromeres shows that an evolutionary perspective can provide compelling, underlying, explicative grounds for contemporary genomic phenomena.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0016-6758
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1226-33
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Primate chromosome evolution: with reference to marker order and neocentromeres.
pubmed:affiliation
Department of Evolutionary Biology, University of Florence, Florence, Italy 50122. roscoe.stanyon@unifi.it
pubmed:publicationType
Journal Article