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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4941
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pubmed:dateCreated |
1990-2-23
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pubmed:abstractText |
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2105528-Animals,
pubmed-meshheading:2105528-B-Lymphocytes,
pubmed-meshheading:2105528-Base Sequence,
pubmed-meshheading:2105528-Binding Sites,
pubmed-meshheading:2105528-Cell Line,
pubmed-meshheading:2105528-Cloning, Molecular,
pubmed-meshheading:2105528-DNA,
pubmed-meshheading:2105528-Enhancer Elements, Genetic,
pubmed-meshheading:2105528-Genes, Immunoglobulin,
pubmed-meshheading:2105528-Humans,
pubmed-meshheading:2105528-Immunoglobulin kappa-Chains,
pubmed-meshheading:2105528-Immunoglobulin mu-Chains,
pubmed-meshheading:2105528-Macromolecular Substances,
pubmed-meshheading:2105528-Mice,
pubmed-meshheading:2105528-Molecular Sequence Data,
pubmed-meshheading:2105528-Plasmids,
pubmed-meshheading:2105528-Protein Conformation,
pubmed-meshheading:2105528-Saccharomyces cerevisiae,
pubmed-meshheading:2105528-Transcription, Genetic,
pubmed-meshheading:2105528-Transcription Factors,
pubmed-meshheading:2105528-Transfection,
pubmed-meshheading:2105528-Transformation, Genetic
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pubmed:year |
1990
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pubmed:articleTitle |
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
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pubmed:affiliation |
Howard Hughes Medical Institute, Philadelphia, PA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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