Linked Life Data

2105258

Source:http://linkedlifedata.com/resource/pubmed/id/2105258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-3-15
pubmed:abstractText
1. This study measured reductions in diastolic blood pressure to arachidonic acid (AA, 0.125-2.0 mg/kg i.v.) in 14-day streptozotocin-diabetic (60 mg/kg i.v.) and control rats anaesthetized with pentobarbitone (50-70 mg/kg i.p.) having been treated acutely or chronically with saline or ponalrestat (25 mg/kg p.o. 1 hr prior to anaesthesia, or 25 mg/kg p.o. daily for 14 days). 2. Streptozotocin-treated diabetic rats displayed reduced sensitivity to depressor effects of AA (0.125-2.0 mg/kg) when compared with controls. 3. Acute treatment with ponalrestat did not change responses to AA in controls or diabetics, whereas chronic treatment resulted in a small increase in depressor responses to AA (0.125, 0.25 and 2.0 mg/kg) in diabetics but not controls. 4. The mechanism of this action of ponalrestat remains to be elucidated, although the results are compatible with the hypothesis that increased polyol pathway activity may affect responses to, or metabolism of eicosanoids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of ponalrestat on depressor responses to arachidonic acid in streptozotocin-diabetic rats.
pubmed:affiliation
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't