| pubmed-article:21048008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1514228 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1561577 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1514811 | lld:lifeskim |
| pubmed-article:21048008 | lifeskim:mentions | umls-concept:C1706462 | lld:lifeskim |
| pubmed-article:21048008 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21048008 | pubmed:dateCreated | 2011-1-3 | lld:pubmed |
| pubmed-article:21048008 | pubmed:abstractText | Staphylococcus aureus clinical isolates with vancomycin MICs of 2 ?g/ml have been associated with vancomycin therapeutic failure and the heteroresistant vancomycin-intermediate S. aureus (hVISA) phenotype. A population analysis profile (PAP) with an area under the curve (AUC) ratio of ? 0.9 for the AUC of the clinical isolate versus the AUC for hVISA strain Mu3 is most often used for determining hVISA, but it is time-consuming and labor-intensive. A collection of 140 MRSA blood isolates with vancomycin MICs of 2 ?g/ml by reference broth microdilution and screened for hVISA using PAP-AUC (21/140 [15%] hVISA) were tested by additional methods to detect hVISA. The methods included (i) Etest macromethod using vancomycin and teicoplanin test strips, brain heart infusion (BHI) agar, and a 2.0 McFarland inoculum; (ii) Etest glycopeptide resistance detection (GRD) using vancomycin-teicoplanin double-sided gradient test strips on Mueller-Hinton agar (MHA) with 5% sheep blood and a 0.5 McFarland inoculum; and (iii) BHI screen agar plates containing 4 ?g/ml vancomycin and 16 g/liter casein using 0.5 and 2.0 McFarland inocula. Each method was evaluated using PAP-AUC as the reference method. The sensitivity of each method for detecting hVISA was higher when the results were read at 48 h. The Etest macromethod was 57% sensitive and 96% specific, Etest GRD was 57% sensitive and 97% specific, and BHI screen agar was 90% sensitive and 95% specific with a 0.5 McFarland inoculum and 100% sensitive and 68% specific with a 2.0 McFarland inoculum. BHI screen agar with 4 ?g/ml vancomycin and casein and a 0.5 McFarland inoculum had the best sensitivity and specificity combination, was easy to perform, and may be useful for clinical detection of hVISA. | lld:pubmed |
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| pubmed-article:21048008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21048008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21048008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21048008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21048008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21048008 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21048008 | pubmed:issn | 1098-660X | lld:pubmed |
| pubmed-article:21048008 | pubmed:author | pubmed-author:FarleyMonica... | lld:pubmed |
| pubmed-article:21048008 | pubmed:author | pubmed-author:SatolaSarah... | lld:pubmed |
| pubmed-article:21048008 | pubmed:author | pubmed-author:PatelJean BJB | lld:pubmed |
| pubmed-article:21048008 | pubmed:author | pubmed-author:AndersonKaren... | lld:pubmed |
| pubmed-article:21048008 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21048008 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:21048008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21048008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21048008 | pubmed:pagination | 177-83 | lld:pubmed |
| pubmed-article:21048008 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:meshHeading | pubmed-meshheading:21048008... | lld:pubmed |
| pubmed-article:21048008 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21048008 | pubmed:articleTitle | Comparison of detection methods for heteroresistant vancomycin-intermediate Staphylococcus aureus, with the population analysis profile method as the reference method. | lld:pubmed |
| pubmed-article:21048008 | pubmed:affiliation | Emory University School of Medicine, Atlanta, Georgia, USA. ssatola@emory.edu | lld:pubmed |
| pubmed-article:21048008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21048008 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21048008 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:21048008 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
