| pubmed-article:21045147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0971285 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21045147 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:21045147 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:21045147 | pubmed:dateCreated | 2010-11-16 | lld:pubmed |
| pubmed-article:21045147 | pubmed:abstractText | The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report that Aur-A promotes breast cancer metastasis. Aur-A overexpression enhanced mammary cell migration by dephosphorylation and activation of cofilin, which facilitates actin reorganization and polymerization. Cofilin knockdown impaired Aur-A-driven cell migration and protrusion of the cell membrane. Conversely, overexpression of activated cofilin abrogated the effects of Aur-A knockdown on cell migration. Moreover, Aur-A overexpession increased the expression of the cofilin phosphatase Slingshot-1 (SSH1), contributing to cofilin activation and cell migration. We found that phosphatidylinositol 3-kinase (PI3K) inhibition blocked Aur-A-induced cofilin dephosphorylation, actin reorganization, and cell migration, suggesting crosstalk with PI3K signaling and a potential benefit of PI3K inhibition in tumors with deregulated Aur-A. Additionally, we found an association between Aur-A overexpression and cofilin activity in breast cancer tissues. Our findings indicate that activation of the cofilin-F-actin pathway contributes to tumor cell migration and metastasis enhanced by Aur-A, revealing a novel function for mitotic Aur-A kinase in tumor progression. | lld:pubmed |
| pubmed-article:21045147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21045147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21045147 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21045147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21045147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21045147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21045147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21045147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21045147 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:21045147 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:MEOLL | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:ZhaoYanY | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:TAWR LRL | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:XingDaD | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:XiangJinJ | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:WangLi-huiLH | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:KangZhuangZ | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:ChenTong-shen... | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:LiuQuentinQ | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:YueCai-fengCF | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:ZhengFei-meng... | lld:pubmed |
| pubmed-article:21045147 | pubmed:author | pubmed-author:ChenJin-naJN | lld:pubmed |
| pubmed-article:21045147 | pubmed:copyrightInfo | Copyright © 2010 AACR. | lld:pubmed |
| pubmed-article:21045147 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21045147 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21045147 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:21045147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21045147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21045147 | pubmed:pagination | 9118-28 | lld:pubmed |
| pubmed-article:21045147 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
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| pubmed-article:21045147 | pubmed:meshHeading | pubmed-meshheading:21045147... | lld:pubmed |
| pubmed-article:21045147 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21045147 | pubmed:articleTitle | The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway. | lld:pubmed |
| pubmed-article:21045147 | pubmed:affiliation | State Key Laboratory of Oncology in South China, Cancer Center, and Sun Yat-sen Institute of Hematology, Sun Yat-sen University, Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. | lld:pubmed |
| pubmed-article:21045147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21045147 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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