Linked Life Data

21042997

Source:http://linkedlifedata.com/resource/pubmed/id/21042997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-11-2
pubmed:abstractText
Investigation of osteoclastogenesis in vivo, especially in early development, has proven difficult because of the accessibility of these early embryonic stages. Our ability to culture embryonic stem cells (ESCs) in vitro has overcome this difficulty as these versatile cells can be expanded endlessly. Thus, the whole process of osteoclastogenesis can be monitored in these cultures through the microscope and with the help of molecular biology techniques. We have developed two methods to induce osteoclasts, the bone matrix remodeling cells, from murine ESCs. Surprisingly, one of these induction methods produces osteoclasts, osteoblasts, and also endothelial cells in the same culture dish. Hence, it is likely that ESCs in culture mimic the in vivo development of osteoclasts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1940-6029
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
690
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-53
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.
pubmed:affiliation
Max Planck Institute for Infection Biology, Berlin, Germany. tsuneto@mpiib-berlin.mpg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't