Linked Life Data

21042550

Source:http://linkedlifedata.com/resource/pubmed/id/21042550

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pubmed-article:21042550pubmed:abstractTextThe purpose of this study was to develop a novel, highly water-soluble poly(L-?-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel (PTX). PGG-PTX is a modification of poly(L-glutamic acid)- paclitaxel conjugate (PGA-PTX) in which an additional glutamic acid has been added to each glutamic side chain in the polymer. PGG-PTX has higher water-solubility and faster dissolution than PGA-PTX. Unlike PGA-PTX, PGG-PTX self-assembles into nanoparticles, whose size remains in the range of 12-15 nm over the concentration range from 25 to 2,000 ?g/mL in saline. Its critical micellar concentration in saline was found to be ~25 ?g/mL. The potency of PGG-PTX when tested in vitro against the human lung cancer H460 cell line was comparable to other known polymer-PTX conjugates. However, PGG-PTX possesses lower toxicity compared with PGA-PTX in mice. The maximum tolerated dose of PGG-PTX was found to be 350 mg PTX/kg, which is 2.2-fold higher than the maximum tolerated dose of 160 mg PTX/kg reported for the PGA-PTX. This result indicates that PGG-PTX was substantially less toxic in vivo than PGA-PTX.lld:pubmed
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pubmed-article:21042550pubmed:articleTitleSynthesis, characterization, and biological evaluation of poly(L-?-glutamyl-glutamine)- paclitaxel nanoconjugate.lld:pubmed
pubmed-article:21042550pubmed:affiliationNitto Denko Technical Corporation, Oceanside, CA 92058, USA.lld:pubmed
pubmed-article:21042550pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21042550pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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