Linked Life Data

21042550

Source:http://linkedlifedata.com/resource/pubmed/id/21042550

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-11-2
pubmed:abstractText
The purpose of this study was to develop a novel, highly water-soluble poly(L-?-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel (PTX). PGG-PTX is a modification of poly(L-glutamic acid)- paclitaxel conjugate (PGA-PTX) in which an additional glutamic acid has been added to each glutamic side chain in the polymer. PGG-PTX has higher water-solubility and faster dissolution than PGA-PTX. Unlike PGA-PTX, PGG-PTX self-assembles into nanoparticles, whose size remains in the range of 12-15 nm over the concentration range from 25 to 2,000 ?g/mL in saline. Its critical micellar concentration in saline was found to be ~25 ?g/mL. The potency of PGG-PTX when tested in vitro against the human lung cancer H460 cell line was comparable to other known polymer-PTX conjugates. However, PGG-PTX possesses lower toxicity compared with PGA-PTX in mice. The maximum tolerated dose of PGG-PTX was found to be 350 mg PTX/kg, which is 2.2-fold higher than the maximum tolerated dose of 160 mg PTX/kg reported for the PGA-PTX. This result indicates that PGG-PTX was substantially less toxic in vivo than PGA-PTX.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1178-2013
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-37
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis, characterization, and biological evaluation of poly(L-?-glutamyl-glutamine)- paclitaxel nanoconjugate.
pubmed:affiliation
Nitto Denko Technical Corporation, Oceanside, CA 92058, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't