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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1991-10-24
|
| pubmed:abstractText |
We study retrospectively the viral replication state (HBV) of 50 patients with chronic hepatic alterations. The seric DNA-HBV and/or intrahepatic (molecular hybridization), the intrahepatic distribution of HBV antigens (specific monoclonal antibodies labelled with immunoperoxidase), conventional seric HBV markers (commercial enzymoimmunoessay) and the different histopathologic features. We found a correlation between DNA-HBV "in situ" and HBcAg intrahepatic and the seric DNA-HBV production. 81% of the patients with HBsAg (+) had intrahepatic HBcAg and 85% (11/13) of them showed the antigen in their cytoplasms. Patients with HBcAg also had seric and liver DNA-HBV (+). The lack of seric HBsAg did not mean that non-active replication of HBV did not exist because 20% of the patients with HBsAg (-) showed seric and "in situ" DNA-HBV and cytoplasmic HBcAg. The detection of DNA-HBV in endothelial cells and vascular elements in hepatic tissue show that the rate of the HBV host cells is greater.
|
| pubmed:language |
spa
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0212-7199
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
505-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2104095-Adolescent,
pubmed-meshheading:2104095-Adult,
pubmed-meshheading:2104095-Aged,
pubmed-meshheading:2104095-Biological Markers,
pubmed-meshheading:2104095-Child,
pubmed-meshheading:2104095-Child, Preschool,
pubmed-meshheading:2104095-Chronic Disease,
pubmed-meshheading:2104095-DNA, Viral,
pubmed-meshheading:2104095-Female,
pubmed-meshheading:2104095-Hepatitis,
pubmed-meshheading:2104095-Hepatitis B Antibodies,
pubmed-meshheading:2104095-Hepatitis B Antigens,
pubmed-meshheading:2104095-Hepatitis B virus,
pubmed-meshheading:2104095-Humans,
pubmed-meshheading:2104095-Infant,
pubmed-meshheading:2104095-Liver,
pubmed-meshheading:2104095-Male,
pubmed-meshheading:2104095-Middle Aged,
pubmed-meshheading:2104095-Retrospective Studies,
pubmed-meshheading:2104095-Virus Replication
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
[Hepatitis B virus (HBV) replication in patients with various types of chronic hepatopathy].
|
| pubmed:affiliation |
Departamento de Microbiología e Inmunología, Universidad del País Vasco, UPV/EHU, Hospital Civil de Bilbao.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|