Linked Life Data

21037388

Source:http://linkedlifedata.com/resource/pubmed/id/21037388

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-1
pubmed:abstractText
?-klotho was first identified as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, and a regulator of calcium homeostasis. ?-kl is expressed in the parathyroid glands, choroid plexus and kidney, where ?-Kl binds to Na(+), K(+)-ATPase. Low extracellular calcium concentrations trigger rapid translocation of ?-Kl/Na(+), K(+)-ATPase complex from endosomal organella to the plasma membrane. This may lead to the PTH secretion in parathyroid glands and transepithelial transport of calcium in kidney and choroid plexus. FGF members are divided into 7 subfamilies. Among them, metabolic FGF subfamily, consisted of FGF19, FGF21 and FGF23, is characterized as their hormonal effects. Indeed,FGF23 is secreted from bone and is circulated to kidney where FGF23 tranceduces signals that suppress vitamin D synthesis and phosphate reabsorption fgf23 deficient phenotypes were reminiscent of those of mice lacking the ?-kl gene, which led us the discovery of molecular interaction and functional crosstalk of ?-Kl and FGF23. FGF23 binds to ?-Kl and converts the canonical FGF receptor 1c to specific for FGF23 and we proposed a comprehensive regulatory scheme of mineral homeostasis involving the mutually regulated positive/negative feedback actions of ?-Kl, FGF23, PTH and 1,25 (OH) (2)D. ?-Kl and FGF23 are novel regulators that integrate the fields of mineral homeostasis, life-style related diseases and aging. This newly established field is widely and remarkably progressing and expected to be fruitful.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0917-5857
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1677-85
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Regulation of calcium homeostasis by ?-Klotho and FGF23].
pubmed:affiliation
Institute of Biomedical Research and Innovation Foundation for Biomedical Research and Innovation.
pubmed:publicationType
Journal Article, English Abstract, Review