Source:http://linkedlifedata.com/resource/pubmed/id/21036197
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-1-11
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| pubmed:abstractText |
Family, twin, and adoption studies have indicated that human intelligence quotient (IQ) has significant genetic components. We performed a low-density genome-wide association analysis with a family-based association test to identify genetic variants influencing IQ, as measured by Wechsler Adult Intelligence Scale full-score IQ (FSIQ). We examined 11,120 single-nucleotide polymorphisms (SNPs) from the Affymetrix GeneChips 10K mapping array genotyped in 292 nuclear families from Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A replication analysis was performed using part of International Multi-Center ADHD Genetics Project (IMAGE) dataset. Twenty-two SNPs were identified as having suggestive associations with IQ (p<10(-3)) in the COGA sample and eleven of the SNPs were located within known genes. In particular, NTM at 11q25 (rs411280, p = 0.000764) and NR3C2 at 4q31.1 (rs3846329, p = 0.000675) were two novel genes which have not been associated with IQ in other studies. It has been reported that NTM might play a role in late-onset Alzheimer disease while NR3C2 may be associated with cognitive function and major depression. The associations of these two genes were well-replicated by single-marker and haplotype analyses in the IMAGE sample. In conclusion, our findings provide evidence that chromosome regions of 11q25 and 4q31.1 contain genes affecting IQ. This study will serve as a resource for replication in other populations.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 GM31575,
http://linkedlifedata.com/resource/pubmed/grant/R01MH081803,
http://linkedlifedata.com/resource/pubmed/grant/R01MH62873,
http://linkedlifedata.com/resource/pubmed/grant/U10AA08401,
http://linkedlifedata.com/resource/pubmed/grant/U10AA08403
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1878-4216
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| pubmed:author | |
| pubmed:copyrightInfo |
Published by Elsevier Inc.
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
35
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
154-60
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| pubmed:meshHeading |
pubmed-meshheading:21036197-Adolescent,
pubmed-meshheading:21036197-Adult,
pubmed-meshheading:21036197-Aged,
pubmed-meshheading:21036197-Alcoholism,
pubmed-meshheading:21036197-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:21036197-Chromosomes, Human, Pair 11,
pubmed-meshheading:21036197-Chromosomes, Human, Pair 4,
pubmed-meshheading:21036197-Family Health,
pubmed-meshheading:21036197-Female,
pubmed-meshheading:21036197-GPI-Linked Proteins,
pubmed-meshheading:21036197-Genome-Wide Association Study,
pubmed-meshheading:21036197-Haplotypes,
pubmed-meshheading:21036197-Humans,
pubmed-meshheading:21036197-Intelligence,
pubmed-meshheading:21036197-Intelligence Tests,
pubmed-meshheading:21036197-International Cooperation,
pubmed-meshheading:21036197-Male,
pubmed-meshheading:21036197-Middle Aged,
pubmed-meshheading:21036197-Neural Cell Adhesion Molecules,
pubmed-meshheading:21036197-Polymorphism, Single Nucleotide,
pubmed-meshheading:21036197-Receptors, Glucocorticoid,
pubmed-meshheading:21036197-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.
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| pubmed:affiliation |
Department of Mathematics and Statistics, College of Arts and Sciences, East Tennessee State University, Johnson City, TN 37614, USA.
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| pubmed:publicationType |
Journal Article,
Multicenter Study,
Research Support, N.I.H., Extramural
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