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rdf:type |
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lifeskim:mentions |
umls-concept:C0030956,
umls-concept:C0205117,
umls-concept:C0208973,
umls-concept:C0456387,
umls-concept:C1280500,
umls-concept:C1514562,
umls-concept:C1517892,
umls-concept:C1521805,
umls-concept:C1704666,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
2
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
We recently described anti-atherogenic properties of the dual domain peptide Ac-hE18A-NH(2) derived by covalently linking the heparin binding domain 141-150 of apoE to 18A, a class A amphipathic helical peptide. In this paper we have compared the properties of Ac-hE18A-NH(2) with the non-heparin binding 151-160 region of apoE linked to 18A (Ac-nhE18A-NH(2)).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
213
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-57
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pubmed:meshHeading |
pubmed-meshheading:21030022-Animals,
pubmed-meshheading:21030022-Apolipoproteins E,
pubmed-meshheading:21030022-Aryldialkylphosphatase,
pubmed-meshheading:21030022-Atherosclerosis,
pubmed-meshheading:21030022-Cholesterol,
pubmed-meshheading:21030022-Endothelial Cells,
pubmed-meshheading:21030022-Female,
pubmed-meshheading:21030022-Hep G2 Cells,
pubmed-meshheading:21030022-Heparan Sulfate Proteoglycans,
pubmed-meshheading:21030022-Humans,
pubmed-meshheading:21030022-Lipoproteins,
pubmed-meshheading:21030022-Lipoproteins, LDL,
pubmed-meshheading:21030022-Mice,
pubmed-meshheading:21030022-Monocytes,
pubmed-meshheading:21030022-Peptide Fragments,
pubmed-meshheading:21030022-Protein Structure, Secondary,
pubmed-meshheading:21030022-Protein Structure, Tertiary,
pubmed-meshheading:21030022-Triglycerides
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pubmed:year |
2010
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pubmed:articleTitle |
Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.
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pubmed:affiliation |
Atherosclerosis Research Unit and Department of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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