Linked Life Data

2101403

Source:http://linkedlifedata.com/resource/pubmed/id/2101403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-9-6
pubmed:abstractText
beta-Adrenergic receptor stimulation is thought to participate in the perinatal switchover of the lung to air-breathing. In the current study, we have determined whether prenatal exposure of rats to terbutaline (10 mg/kg on gestational days 17,18 and 19) exerts promotional effects on lung function solely through its immediate actions at beta-receptors or whether terbutaline influences subsequent reactivity to adrenergic stimuli; we have contrasted the effects with those seen with a glucocorticoid (dexamethasone, 0.8 mg/kg on gestational days 17, 18 and 19). On postnatal day 3, basal lung compliance and lung rupture volumes were reduced after treatment with either terbutaline or dexamethasone, effects related primarily to drug-induced growth retardation; these effects were not present if data were corrected for relative tissue size. Despite a slightly reduced basal compliance, prenatal terbutaline exposure markedly enhanced postnatal reactivity to acute challenge with isoproterenol. In contrast, dexamethasone primarily enhanced basal compliance (corrected for weight deficits), with only minor effects on the isoproterenol response. These results suggest that, rather than producing classical receptor desensitization, gestational exposure to a beta-agonist sensitizes lung compliance to postnatal beta-receptor stimulation. Promotional effects of terbutaline on neonatal lung function are thus distinct from functional changes achieved with glucocorticoids, such as dexamethasone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0141-9846
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Regulation of neonatal rat lung compliance by beta-adrenergic receptor stimulation: effects of prenatal exposure to terbutaline or dexamethasone.
pubmed:affiliation
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.