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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1978-10-18
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pubmed:abstractText |
Cells from neonatal rat livers were unable to maintain DNA-synthetic activity in calcium-deficient medium, but neoplastic hepatocytes from Morris hepatomas 5123 tc and 7795 synthesized DNA and proliferated indefinitely in this calcium-deficient medium. The calcium content of fresh hepatoma tissue from which these cultures were derived was as much as 10 times greater than that of normal liver; but this difference could not account for the insensitivity of neoplastic cells to extracellular calcium because it disappeared during subsequent cultivation in vitro.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0073-5655
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-35
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:210108-Animals,
pubmed-meshheading:210108-Calcium,
pubmed-meshheading:210108-Carcinoma, Hepatocellular,
pubmed-meshheading:210108-Cell Division,
pubmed-meshheading:210108-Cell Transformation, Neoplastic,
pubmed-meshheading:210108-Cells, Cultured,
pubmed-meshheading:210108-DNA,
pubmed-meshheading:210108-Liver,
pubmed-meshheading:210108-Liver Neoplasms,
pubmed-meshheading:210108-Rats
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pubmed:year |
1978
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pubmed:articleTitle |
The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes.
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pubmed:publicationType |
Journal Article
|