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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-11-18
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pubmed:abstractText |
Idiopathic Pulmonary Fibrosis (IPF) is an unresolved clinical issue. Phosphodiesterases (PDEs) are known therapeutic targets for various proliferative lung diseases. Lung PDE6 expression and function has received little or no attention. The present study aimed to characterize (i) PDE6 subunits expression in human lung, (ii) PDE6 subunits expression and alteration in IPF and (iii) functionality of the specific PDE6D subunit in alveolar epithelial cells (AECs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
pubmed-author:EickelbergOliverO,
pubmed-author:GhofraniHossein AHA,
pubmed-author:GrimmingerFriedrichF,
pubmed-author:GuentherAndreasA,
pubmed-author:KlepetkoWalterW,
pubmed-author:KonigshoffMelanieM,
pubmed-author:NikolovaSevdalinaS,
pubmed-author:PullamsettiSoni SSS,
pubmed-author:SavaiRajkumarR,
pubmed-author:SchermulyRalph TRT,
pubmed-author:SeegerWernerW,
pubmed-author:VoswinckelRobertR,
pubmed-author:WeissmannNorbertN
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146
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pubmed:meshHeading |
pubmed-meshheading:20979602-Cyclic Nucleotide Phosphodiesterases, Type 6,
pubmed-meshheading:20979602-Down-Regulation,
pubmed-meshheading:20979602-Female,
pubmed-meshheading:20979602-Gene Expression Regulation,
pubmed-meshheading:20979602-Humans,
pubmed-meshheading:20979602-Idiopathic Pulmonary Fibrosis,
pubmed-meshheading:20979602-Immunohistochemistry,
pubmed-meshheading:20979602-Lung,
pubmed-meshheading:20979602-Male,
pubmed-meshheading:20979602-Middle Aged,
pubmed-meshheading:20979602-RNA, Messenger,
pubmed-meshheading:20979602-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
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pubmed:affiliation |
University of Giessen Lung Centre, Giessen, Germany.
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pubmed:publicationType |
Journal Article
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