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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-10-27
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pubmed:abstractText |
The use of opioids in treating pain is limited due to significant side effects including somnolence, constipation, analgesic tolerance, addiction and respiratory depression. Pre-clinical studies have shown that neurokinin 1 (NK(1) ) receptor antagonists block opioid-induced antinociceptive tolerance and may inhibit opioid-induced rewarding behaviours. Here, we have characterized a bifunctional peptide with both opioid agonist and NK(1) antagonist pharmacophores in a rodent model of neuropathic pain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 The Authors. British Journal of Pharmacology © 2010 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
986-1001
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:20977451-Analgesics, Opioid,
pubmed-meshheading:20977451-Animals,
pubmed-meshheading:20977451-Behavior, Animal,
pubmed-meshheading:20977451-Disease Models, Animal,
pubmed-meshheading:20977451-Dose-Response Relationship, Drug,
pubmed-meshheading:20977451-Drug Tolerance,
pubmed-meshheading:20977451-Injections, Intravenous,
pubmed-meshheading:20977451-Injections, Spinal,
pubmed-meshheading:20977451-Male,
pubmed-meshheading:20977451-Motor Skills,
pubmed-meshheading:20977451-Neuralgia,
pubmed-meshheading:20977451-Oligopeptides,
pubmed-meshheading:20977451-Pain Measurement,
pubmed-meshheading:20977451-Rats,
pubmed-meshheading:20977451-Rats, Sprague-Dawley,
pubmed-meshheading:20977451-Receptors, Neurokinin-1,
pubmed-meshheading:20977451-Receptors, Opioid
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pubmed:year |
2010
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pubmed:articleTitle |
Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
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pubmed:affiliation |
Department of Pharmacology, College of Medicine and Department of Chemistry, University of Arizona, Tucson, AZ 85724, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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