20975899

Source:http://linkedlifedata.com/resource/pubmed/id/20975899

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017428, umls-concept:C0029235, umls-concept:C0392673, umls-concept:C0563594
pubmed:issue	8
pubmed:dateCreated	2010-10-26
pubmed:abstractText	One of the central issues of evolutionary genomics is to find out the adaptive strategies of microorganisms to stabilize nucleic acid molecules under high temperature. Thermal adaptation hypothesis gives a link between G+C content and growth temperature if there is a considerable variation of guanine and cytosine content between species. However, there has been a long-standing debate regarding the correlations between genomic GC content and optimal growth temperature (Topt). We urged that adaptation to growth at high temperature requires a coordinated set of evolutionary changes affecting: (i) nucleic acid thermostability and (ii) stability of codon-anticodon interactions. Moreover, in Bacillaceae family we have demonstrated that a higher genomic GC level do not have any role in stabilizing mRNA secondary structure at high growth temperature. Comparative analysis between homologous sequences of thermophilic Thermus thermophilus and mesophilic Deinococcus radiodurans suggests that increased levels of GC contents in the coding sequence corresponding to strand structure of Thermus thermophilus genes have stabilizing effect on the mRNA secondary structure, whereas increased levels of GC contents in coding sequences corresponding to aperiodic structure have destabilizing effect on the mRNA secondary structure. In this perspective, a critical review of thermal adaptation hypothesis is further advocated.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101258255
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	0973-2063
pubmed:author	pubmed-author:BasakSurajitS, pubmed-author:GhoshTapash ChandraTC, pubmed-author:GuptaSanjib KumarSK, pubmed-author:MukhopadhyayPamelaP
pubmed:issnType	Electronic
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	352-6
pubmed:year	2010
pubmed:articleTitle	Genomic adaptation of prokaryotic organisms at high temperature.
pubmed:affiliation	Biomedical Informatics Center, National Institute of Cholera and Enteric Diseases, P-33, C.I.T Road, Scheme-XM, Beliaghata, Kolkata-700010, India.
pubmed:publicationType	Journal Article