Linked Life Data

20974990

Source:http://linkedlifedata.com/resource/pubmed/id/20974990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-18
pubmed:abstractText
The Ag receptors on ?? and ?? T cells differ not only in the nature of the ligands that they recognize but also in their signaling potential. We hypothesized that the differences in ??- and ??TCR signal transduction were due to differences in the intracellular signaling pathways coupled to these two TCRs. To investigate this, we used transcriptional profiling to identify genes encoding signaling molecules that are differentially expressed in mature ?? and ?? T cell populations. Unexpectedly, we found that B lymphoid kinase (Blk), a Src family kinase expressed primarily in B cells, is expressed in ?? T cells but not in ?? T cells. Analysis of Blk-deficient mice revealed that Blk is required for the development of IL-17-producing ?? T cells. Furthermore, Blk is expressed in lymphoid precursors and, in this capacity, plays a role in regulating thymus cellularity during ontogeny.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6518-27
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing ?? T cells.
pubmed:affiliation
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural