| pubmed-article:2097073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C0042878 | lld:lifeskim |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C0043031 | lld:lifeskim |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:2097073 | lifeskim:mentions | umls-concept:C1511572 | lld:lifeskim |
| pubmed-article:2097073 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:2097073 | pubmed:dateCreated | 1991-7-22 | lld:pubmed |
| pubmed-article:2097073 | pubmed:abstractText | In this in vivo study, the time-dependent effect of oral sodium warfarin was studied in male rats synchronized under a 12-hr light-dark cycle (light 0600-1800). Groups of 5 animals received an oral dose of 500 micrograms/kg of warfarin or saline at 0600 or 1800 and 1 mg/kg of vitamin K 8 hr later and the rats were sacrificed 240 min after vitamin K administration. The activities of the vitamin K reductase and vitamin K epoxide reductase were measured indirectly by determining the content of vitamin K1 and vitamin K epoxide reductase in the plasma and liver. The data obtained in control rats indicated that vitamin K and vitamin K 2,3 epoxide concentrations in plasma and liver were higher (P less than 0.05) at 1800 than at 0600. Warfarin had a greater (P less than 0.05) inhibitory effect on the vitamin K and vitamin K-epoxide reductases at 0600 compared to 1800; plasma levels of S- and R-warfarin did not vary with time of administration. The findings suggest that the activity of both reductases under control conditions, and the warfarin-induced inhibition of these enzymes varied depending on the time of drug administration. | lld:pubmed |
| pubmed-article:2097073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2097073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2097073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2097073 | pubmed:issn | 0742-0528 | lld:pubmed |
| pubmed-article:2097073 | pubmed:author | pubmed-author:BélangerP MPM | lld:pubmed |
| pubmed-article:2097073 | pubmed:author | pubmed-author:LabrecqueGG | lld:pubmed |
| pubmed-article:2097073 | pubmed:author | pubmed-author:SoulbanGG | lld:pubmed |
| pubmed-article:2097073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2097073 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:2097073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2097073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2097073 | pubmed:pagination | 403-11 | lld:pubmed |
| pubmed-article:2097073 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:meshHeading | pubmed-meshheading:2097073-... | lld:pubmed |
| pubmed-article:2097073 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2097073 | pubmed:articleTitle | Temporal variation in the effects of warfarin on the vitamin K cycle. | lld:pubmed |
| pubmed-article:2097073 | pubmed:affiliation | Ecole de pharmacie, Université Laval, Québec, Canada. | lld:pubmed |
| pubmed-article:2097073 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2097073 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
