Source:http://linkedlifedata.com/resource/pubmed/id/20966392
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
mutations of the ryanodine receptor (RyR) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These mutations predispose to the generation of Ca waves and delayed afterdepolarizations during adrenergic stimulation. Ca waves occur when either sarcoplasmic reticulum (SR) Ca content is elevated above a threshold or the threshold is decreased. Which of these occurs in cardiac myocytes expressing CPVT mutations is unknown.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4571
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1483-9
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pubmed:meshHeading |
pubmed-meshheading:20966392-Adrenergic Agents,
pubmed-meshheading:20966392-Animals,
pubmed-meshheading:20966392-Calcium,
pubmed-meshheading:20966392-Calcium Signaling,
pubmed-meshheading:20966392-Disease Models, Animal,
pubmed-meshheading:20966392-Isoproterenol,
pubmed-meshheading:20966392-Mice,
pubmed-meshheading:20966392-Mutation, Missense,
pubmed-meshheading:20966392-Myocytes, Cardiac,
pubmed-meshheading:20966392-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:20966392-Sarcoplasmic Reticulum,
pubmed-meshheading:20966392-Tachycardia, Ventricular
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pubmed:year |
2010
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pubmed:articleTitle |
In the RyR2(R4496C) mouse model of CPVT, ?-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves.
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pubmed:affiliation |
Unit of Cardiac Physiology, Manchester Academic Health Sciences Centre, University of Manchester, 46 Grafton St, Manchester M13 9NT, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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