Source:http://linkedlifedata.com/resource/pubmed/id/20957632
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2011-6-28
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| pubmed:abstractText |
We examined oral contraceptive (OC) and menopausal hormonal therapy (MHT) use in relation to risk of B-cell non-Hodgkin lymphoma (NHL). Women under age 85 years participating in the California Teachers Study with no history of hematopoietic cancer were followed from 1995 through 2007. A total of 516 of 114,131 women eligible for OC use analysis and 402 of 54,758 postmenopausal women eligible for MHT use analysis developed B-cell NHL. Multivariable adjusted and age stratified Cox proportional hazards models were fit to estimate relative risks (RRs) and 95% confidence intervals (95% CI). Ever versus never OC use was marginally associated with lower B-cell NHL risk, particularly among women first using OCs before age 25 years (RR=0.72, 95% CI=0.51-0.99); yet, no duration-response effect was observed. No association was observed for ever versus never MHT use among postmenopausal women (RR=1.05, 95% CI=0.83-1.33) overall or by formulation (estrogen alone, ET, or estrogen plus progestin, EPT). Among women with no MHT use, having bilateral oophorectomy plus hysterectomy was associated with greater B-cell NHL risk than having natural menopause (RR=3.15, 95% CI=1.62-6.13). Bilateral oophorectomy plus hysterectomy was not associated with risk among women who used ET or EPT. These results indicate that exogenous hormone use does not strongly influence B-cell NHL risk.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K05 CA136967,
http://linkedlifedata.com/resource/pubmed/grant/N01-PC-35136,
http://linkedlifedata.com/resource/pubmed/grant/N01-PC-35139,
http://linkedlifedata.com/resource/pubmed/grant/N02-PC-15105,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA077398-13,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA77398,
http://linkedlifedata.com/resource/pubmed/grant/U55/CCR921930-02
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1097-0215
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| pubmed:author |
pubmed-author:BernsteinLeslieL,
pubmed-author:ChangEllen TET,
pubmed-author:ClarkeChristina ACA,
pubmed-author:DeapenDennisD,
pubmed-author:DuanLeiL,
pubmed-author:HendersonKatherine DKD,
pubmed-author:LaceyJames VJVJr,
pubmed-author:LuYaniY,
pubmed-author:MaHuiyanH,
pubmed-author:Sullivan-HalleyJaneJ,
pubmed-author:WangSophia SSS
|
| pubmed:copyrightInfo |
Copyright © 2010 UICC.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
129
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
974-82
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| pubmed:meshHeading |
pubmed-meshheading:20957632-Adult,
pubmed-meshheading:20957632-Aged,
pubmed-meshheading:20957632-Aged, 80 and over,
pubmed-meshheading:20957632-California,
pubmed-meshheading:20957632-Cohort Studies,
pubmed-meshheading:20957632-Contraceptives, Oral,
pubmed-meshheading:20957632-Female,
pubmed-meshheading:20957632-Follow-Up Studies,
pubmed-meshheading:20957632-Hormone Replacement Therapy,
pubmed-meshheading:20957632-Humans,
pubmed-meshheading:20957632-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:20957632-Lymphoma, B-Cell,
pubmed-meshheading:20957632-Lymphoma, Follicular,
pubmed-meshheading:20957632-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:20957632-Menopause,
pubmed-meshheading:20957632-Middle Aged,
pubmed-meshheading:20957632-Prospective Studies,
pubmed-meshheading:20957632-Risk Factors,
pubmed-meshheading:20957632-Treatment Outcome
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| pubmed:year |
2011
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| pubmed:articleTitle |
Oral contraceptives, menopausal hormone therapy use and risk of B-cell non-Hodgkin lymphoma in the California Teachers Study.
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| pubmed:affiliation |
Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. yalu@coh.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|