Linked Life Data

20949211

Source:http://linkedlifedata.com/resource/pubmed/id/20949211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-1
pubmed:abstractText
In the present study, the in vivo distribution of polyelectrolyte multilayer coated gold nanoparticles is shown, starting from the living animal down to cellular level. The coating was designed with functional moieties to serve as a potential nano drug for prion disease. With near infrared time-domain imaging we followed the biodistribution in mice up to 7 days after intravenous injection of the nanoparticles. The peak concentration in the head of mice was detected between 19 and 24 h. The precise particle distribution in the brain was studied ex vivo by X-ray microtomography, confocal laser and fluorescence microscopy. We found that the particles mainly accumulate in the hippocampus, thalamus, hypothalamus, and the cerebral cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
2040-3372
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2826-34
pubmed:dateRevised
2011-6-22
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study.
pubmed:affiliation
NanoBioMed Lab @ LANADA (Laboratory for Nanodiagnostics, Drug Delivery and Analysis), CBM-Cluster in Biomedicine S.c.r.l., Basovizza, AREA Science Park, Trieste, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't